Choosing TypeScript over JavaScript for Node.js development can offer numerous benefits. TypeScript, a superset of JavaScript, provides a robust and scalable framework for building large-scale applications, including those run on Node.js.

1. Static Typing: The most significant advantage TypeScript offers over JavaScript is static typing. Static typing means the data type of a variable is checked at compile time, which helps catch errors before the code runs. JavaScript, being dynamically typed, doesn’t offer this level of security, which can lead to runtime errors. Static typing also aids in code documentation, as the type information communicates what the function expects and what it returns.

2. Improved Tooling: TypeScript’s static typing enables better development tools. Features like autocompletion, type inference, and type checking make the development process more efficient and less error-prone. With TypeScript, you can catch a vast majority of errors during the development process itself, rather than discovering them after the deployment.

3. Better Object-Oriented Programming (OOP): TypeScript includes built-in support for implementing object-oriented programming concepts like classes, interfaces, and modules, which JavaScript does not support fully. This makes TypeScript a better option for large-scale applications where code structuring and maintainability are crucial.

4. Backward Compatibility: TypeScript is a superset of JavaScript. This means that valid JavaScript code is also valid TypeScript code. If you’re transitioning from a JavaScript codebase, you can do so incrementally without any breaking changes.

5. Strong Community and Ecosystem: TypeScript, developed and maintained by Microsoft, has a robust and active community. The language has seen steady growth and popularity in the Node.js ecosystem. Moreover, numerous libraries and frameworks have TypeScript definitions, enhancing the developer experience.

6. Easier Debugging: TypeScript’s static typing can help prevent many common mistakes that JavaScript developers encounter, like typos, incorrect uses of ‘null’ or ‘undefined’, and calling functions with the wrong number or type of arguments. All these errors can be caught at compile-time, rather than at runtime, making debugging easier.

7. Better for Large Codebases: TypeScript’s advanced features like namespaces, modules, and interfaces make it more manageable and organized for large codebases. These features can be particularly useful when working with large teams or projects.

In conclusion, while JavaScript is the basis for Node.js and has served its purpose well over the years, TypeScript provides a more modern, safe, and scalable approach. With its static typing and OOP support, TypeScript can lead to more robust, maintainable, and secure Node.js applications, making it a worthy consideration over JavaScript.